Published Works
In 1985 a small Supplement company between Dallas and Ft. Worth sold multiple products made from aloe leaf gel. Due to remarkable health restorations fostered by the company’s aloe beverage 20 million dollars for research and a new company Carrington Laboratories was founded. The goal was to identify the plant made molecule in aloe leaf gel that supported improved health and meet the requirements to make this substance a new FDA approved pharmaceutical. Multiple academic institutions were engaged to conduct the necessary FDA data required for a new drug. Multiple mechanisms for a wide range of benefits were produced and the plant leaf molecule was found to be acetylated mannose (acemannan). 1. The lack of toxicity in required FDA studies (no LD-50 nor LD-100) required for acemannan could be provided. 2. When aloe acemannan was taken orally, every deviation from normal health, physically, mentally, or emotionally improved. These two points were professional heresy, and the new drug application was rejected. Carrington had volumes of data attesting to the health supporting data aloe acemannan supported. The passage of the Dietary Supplement Health and Education Act of 1994 (DSHEA) awakened Carrington to the fact, aloe acemannan is not a drug, nor did it work like a drug and is a dietary supplement ingredient utilized in gene driven cellular synthesis. An international supplement company took acemannan to the marketplace and sold more than a billion dollars of product in the next ten years. This was only due to its support of unmatched health benefits. H.R. McDaniel, M.D. was a medical consultant for Carrington Laboratories . The following publications are selected from the vast number of benefits realized by aloe acemannan being restored to the modern food chain.
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The Effect of an Aloe Polymannose Multi-nutrient Complex on Cognitive and Immune Functioning in Alzheimer’s Disease
Journal of Alzheimer’s Disease 33 (2013) 393–406
DOI 10.3233/JAD-2012-121381
IOS Press 393
Shepherd Air Force Base Retired Military Diabetic Clinic
281 Retired Personal
Test Population Report
Presented at the First Annual Houston Glycemic Convention, Hyatt
3rd National Conference
New Initiatives in the Prevention and Intervention of FAS/FAE for Aboriginal Peoples of Canada ( A Conference syllabus on fetal alcohol syndrome brain damage & repair with proof for generation for millions of adult stem cells from the individual’s own bone marrow)
May 21-22, 2003
Holiday Inn Downtown, Vancouver, BC CANADA
Effects of Nutritional Supplements on Attentional-Deficit Hyperactivity Disorder
K.D. Dykman, R. A. Dykman, Integrative Physiological and Behavioral Science, vol.33 no1. Jan. 1998
Parent and teacher evaluations of 17 students in special education were evaluated serially for 6 weeks for hyperactivity, inattentiveness, and oppositional defiant and compulsive disorders. Significant, progressive improvements were documented.
The Effect of Nutritional Supplementation on Alcoholics: Mood States and Craving for Alcohol
K.D.Dykman, J.Briggs, J. Am. Nutra.Assoc. Supp.1, August 1997.
Five subjects meeting formal criteria for alcoholism were given a glyconutrient formulation for 6 weeks. Craving averaged on a scale of 0 to -10, was initially 4.9 and dropped to 2.8. Improvements in depression, cognition, energy, anger/temper and outlook on life were noted. A 6 month follow up found all cases continued their dietary change and the benefits had persisted.
Case Report: Observed Improvements in Developmental Dyslexia Accompanied by Supplementation with Glyconutrients and Phytonutrients
D.J. Benton, J. Am Nutra. Assoc. Supp. 1, August 1997.
This 8 y/o physician’s son demonstrated academic progress and improved attitude toward school. He went from the lower third of his class in grades to the middle third. Less irritability and frustration with an improved memory was observed.
Glyconutrients and Perception, Cognition, and Memory
A.N. Stancil, L.H. Hicks, Perceptual Mot Skills,10:259-270. 2009.
Drs. Atiya N. Stancil and Leslie H. Hicks, both of Howard University in Washington, D.C., published this randomized, double-blind, placebo-controlled study investigating the impact of glyconutrient complex on the brain function of 62 healthy young college students. The study showed that a single, one tablespoon serving of glyconutrient complex significantly improved visual discrimination and working memory. Student test scores increased when the glyco-nutrients were taken while studying, as compared to a control session composed of the same group.
The Chicago Results Project: Micronutrients Improve Student Attitudes and Academic Performance
A. Yisrael, M. Morris, Proc Fish. Inst. Med. Res. Vol.3, No1, August 2003.
58 total students, 17 kindergartens, 41 grade school, that had exhausted resources of the public school system and were in a private church facility and on medications for ADD/ADHD were provided a glyconutrient-phytonutrient formulation. Teachers reported a marked reduction in student-student and student-teacher conflicts. Attention spans were increased. Disciplinary actions decreased 90%. Property damage was reduced. 12 students no longer required medications. Attendance rose 45%. Tardiness was reduced 50%. Minor illness was decreased 75% Teacher’s rated the school noise level to decrease 95% and learning environment improved 100%.Parent support and cooperation with the school greatly improved and the student behavior and study habits at home were markedly elevated.
Use of Glyconutritional Supplements In Children with Bipolar Disorder: A 10-Month Study
M.F. Zesiewiecz, T.A. Crouch, J Garner. Proc. Fish. Inst. Med.Res.Vol.4, No 2, August 2003.
The Effects of Glyconutritional in Children with Attention Deficit Hyperactivity Disorder
M.F. Zesiewiecz, T.A. Crouch, C. Augilar, Proc. Fish. Inst. Med. Res.Vol.4, No 2, August 2003.
Effects of Glyconutritional Supplements in Children with Bipolar Disorder: A Final Longitudinal Study
M.F. Zesiewiecz, T.A. Crouch, C. Augilar, Proc. Fish. Inst. Med. Res. Vol. 4, No.1, March 2005
20 children with bipolar disorder were serially evaluated including toxic side effects for their psychotropic medications. Glyconutrient supplements were instituted with no change
Phytonutrients and Glyconutrients in Autistic Children
S. Nisinzwelg, Proc.Fish. Inst. Med.Res., Vol. 1, No 3, September 1999.
In 25 autistic children 21 completed the protocol, 4 girls and 21 boys.Glyconutrients and phytochemicals were added to the diet with participants compliant for 3 to 18 months. 17 autistic traits were evaluated by the parents. An average of 82.8% improvement was reported (71% to 95% range). 7 common illnesses were monitored, Asthma was the most responsive and infections were improved. A more formal study with controls was deemed supported by this pilot study’s responses.
Preliminary Investigation into the Benefits of Glyconutrient Supplementation in Learning-Disabled Children.
A. Omelchuk, D. Wells. Proc. Fish. Inst. Med. Res. Vol.3,No. 2, March 2004.
14 Children in The Edmonton, Canada learning disability 5th grade class were evaluated in two phases, 90 days pre-observation and evaluation of 44 specific and 5 general functional disabilities followed by 90 days of glyconutrient and phytochemical intake in their diet. Assessments were a challenge. A combination of teacher, parent and a physician’s observations were combined. Marked improvements were offered in the general categories of behavior, language, cognition, sensory problems, motor coordination and academic performance. The teacher observed that all students were nicer in their interactions with one another, more: cooperative, appreciative, willing workers, task oriented and pleasurable to teach. Significant improvements were found in behavior& performance, as measured by standardized tests and assessment parameters.
Phase I/II Double-Blind, Parallel, Placebo Controlled Study in Patients with AIDS-Related Complex (ARC) of Carissyn* and Retrovir in Combination with Carissyn and Placebo.
N. Clumeck, Brussels, Belgium, Carrington Laboratories, FDA-IND Report #9500
47 patients enrolled. 11, Acemannan only, 12 in placebo, 12 in AZT plus Acemannan, 12 in AZT plus placebo group. In the 24-week study, laboratory panels and physical status were evaluated. Nausea, vomiting and adverse drug reactions of AZT patients were reduced by the addition of Acemannan. CD4 helper lymphocytes were increased in Acemannan patients, but not statistically significant values. No toxicity of Acemannan was noted.
Carrisyn is a trade name for aloe acemannan.
The Effect of Dietary Supplementation on Brain-Derived Neurotrophic Factor and Cognitive Functioning in Alzheimer’s Dementia
Alicia Martin1, Jordan Stillman1, Maria-Jose Miguez2, H. Reginald McDaniel3, Janet Konefal4, Judi M. Woolger5, John E. Lewis1*
- Departments of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States
- School of Integrated Sciences and Humanity at Florida International University, Miami, FL, United States
- Fisher Institute for Medical Research, Grand Prairie, TX, United States
- Department of Family Medicine & Community Health, University of Miami Miller School of Medicine, Miami, FL, United States
- Medicine, University of Miami Miller School of Medicine, Miami, FL, United States
The Effect of a Polysaccharide-Based Multi-nutrient Dietary Supplementation Regimen on Infections and Immune Functioning in Multiple Sclerosis (2018)
H. Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Lucas C. Lages, Laura A. Lantigua, Steven E. Atlas, Judi M. Woolger & John E. Lewis
To cite this article: H. Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Lucas C. Lages, Laura A. Lantigua, Steven E. Atlas, Judi M. Woolger & John E. Lewis (2018):
The Effect of a Polysaccharide-Based Multinutrient Dietary Supplementation Regimen on Infections and Immune Functioning in Multiple Sclerosis, Journal of Dietary Supplements
The Effect of Broad-Spectrum Dietary Supplementation on Quality of Life, Symptom Severity, and Functioning in Multiple Sclerosis (2019)
H. Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Judith Hensel, Laura A. Lantigua, Lucas C. Lages, Steven E. Atlas, Judi M. Woolger & John E. Lewis
To cite this article: H. Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Judith Hensel, Laura A. Lantigua, Lucas C. Lages, Steven E. Atlas, Judi M. Woolger & John E. Lewis (2019):
The Effect of Broad-Spectrum Dietary Supplementation on Quality of Life, Symptom Severity, and Functioning in Multiple Sclerosis, Journal of Dietary Supplements
Relationship between Brain-Derived Neurotrophic Factor and Immune Function during Dietary Supplement Treatment of Elderly with Alzheimer’s Dementia
Jordan Stillman1, Alicia Martin1, Maria-Jose Miguez2, H. Reginald McDaniel3, Janet Konefal4, Judi M. Woolger5, John E. Lewis1*
Departments of 1Psychiatry and Behavioral Sciences, 4Family Medicine and Community Health, 5Medicine, University of Miami Miller School of Medicine, 2School of Integrated Science and Humanity, Florida International University, Miami, Florida, 3Fisher Institute for Medical Research, Grand Prairie, Texas, United States